Myelin Oligodendrocyte Glycoprotein Antibody-Associated Optic Neuritis-A Review.

Kaushik, Megha and Burdon, Michael A (2021) Myelin Oligodendrocyte Glycoprotein Antibody-Associated Optic Neuritis-A Review. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. ISSN 1536-5166.

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Our understanding of demyelinating optic neuritis has substantially evolved over the past 2 decades. With advancements in serological testing, antibodies against myelin oligodendrocyte glycoprotein (MOG) have been recently discovered in a distinct subset of demyelinating neuroinflammatory disease. Although MOG-immunoglobulin G (IgG)-associated disorder (MOGAD) has previously been seen as a component of neuromyelitis optica spectrum disorder (NMOSD), evidence increasingly suggests that it should be distinguished as a separate condition. The distinction of MOGAD from aquaporin-4 IgG NMOSD is imperative as treatment plans need to be tailored to its unique disease course and prognosis. The purpose of this review is to explore the nature and outcomes of MOGAD optic neuritis to help guide acute and long-term immunosuppressive treatment decisions.

Item Type: Article
Subjects: WW Eyes. Ophthalmology
Divisions: Ambulatory Care > Ophthalmology
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Depositing User: Mr Philip O'Reilly
Date Deposited: 28 Apr 2021 08:25
Last Modified: 28 Apr 2021 08:25

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