Sinusoidal endothelial cells as orchestrators of the gut liver immune axis.

Adams, David H (2021) Sinusoidal endothelial cells as orchestrators of the gut liver immune axis. Hepatology (Baltimore, Md.). ISSN 1527-3350. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: http://onlinelibrary.wiley.com/journal/10.1002/(IS...

Abstract

The paper by Gola and colleagues published recently in Nature uses an array of state-of-the-art techniques to demonstrate how commensal organisms shape protective immunity in the liver by organising immune cells into anatomical zones that are closely related to blood flow into the liver from the gut via the portal venous system. Sophisticated confocal imaging is used to map leukocyte distribution within the liver, targeted disruption of critical signalling pathways and RNA sequencing of specific cell types to determine molecular and cellular mechanisms and murine models of bacterial and malarial infection to demonstrate functional relevance.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: QW Microbiology. Immunology
WI Digestive system. Gastroenterology
Divisions: Clinical Support > Immunology
Related URLs:
Depositing User: Jamie Edgar
Date Deposited: 10 May 2021 15:03
Last Modified: 10 May 2021 15:03
URI: http://www.repository.uhblibrary.co.uk/id/eprint/4299

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