Lactic acidosis, hypoglycaemia and eosinophilia: novel markers of antibody mediated rejection causing graft ischaemia.

Halle-Smith, James M, Hann, Angus, Cain, Owen L, Perera, M Thamara P R and Neil, Desley A H (2021) Lactic acidosis, hypoglycaemia and eosinophilia: novel markers of antibody mediated rejection causing graft ischaemia. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. ISSN 1527-6473. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: http://onlinelibrary.wiley.com/journal/10.1002/(IS...

Abstract

Historically, minimal significance has been given to the humoral immune response after liver transplantation and, despite antibodies against HLA antigens being present in 10-20% of patients awaiting transplant, the incidence of antibody mediated rejection (AMR) after ABO compatible (ABO-C) liver transplantation is low (1).Donor Specific Antibodies (DSA) can lead to early graft loss (2), but most patients awaiting liver transplant are not screened for HLA sensitisation and serum DSA measurement are only undertaken if AMR is suspected. We describe two cases of AMR occurring within one week of ABO-C liver transplantation with previously unreported biochemical and histological characteristics.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: QW Microbiology. Immunology
QZ Pathology. Oncology
WI Digestive system. Gastroenterology
Divisions: Clinical Support > Immunology
Related URLs:
Depositing User: Jamie Edgar
Date Deposited: 03 Jun 2021 11:42
Last Modified: 03 Jun 2021 11:42
URI: http://www.repository.uhblibrary.co.uk/id/eprint/4360

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