Establishing the prevalence of common tissue-specific autoantibodies following SARS CoV-2 infection.

Richter, Alex G, Shields, Adrian M, Karim, Abid, Birch, David, Faustini, Sian E, Steadman, Lora, Ward, Kerensa, Plant, Timothy, Reynolds, Gary, Veenith, Tonny, Cunningham, Adam F, Drayson, Mark T and Wraith, David C (2021) Establishing the prevalence of common tissue-specific autoantibodies following SARS CoV-2 infection. Clinical and experimental immunology. ISSN 1365-2249.

Full text not available from this repository.
Official URL: 10.1111/cei.13623.

Abstract

COVID-19 has been associated with both transient and persistent systemic symptoms that do not appear to be a direct consequence of viral infection. The generation of autoantibodies has been proposed as a mechanism to explain these symptoms. To understand the prevalence of autoantibodies associated with SARS-CoV-2 infection, we investigated the frequency and specificity of clinically relevant autoantibodies in 84 individuals previously infected with SARS-CoV-2, suffering from COVID-19 of varying severity in both the acute and convalescent setting. These were compared with results from 32 individuals who were on ITU for non-COVID reasons. We demonstrate a higher frequency of autoantibodies in the COVID-19 ITU group compared with non-COVID-19 ITU disease control patients and that autoantibodies were also found in the serum 3-5 months post COVID-19 infection. Non-COVID patients displayed a diverse pattern of autoantibodies; in contrast, the COVID-19 groups had a more restricted panel of autoantibodies including skin, skeletal muscle and cardiac antibodies. Our results demonstrate that respiratory viral infection with SARS-CoV-2 is associated with the detection of a limited profile of tissue-specific autoantibodies, detectable using routine clinical immunology assays. Further studies are required to determine whether these autoantibodies are specific to SARS-CoV-2 or a phenomenon arising from severe viral infections and to determine the clinical significance of these autoantibodies.

Item Type: Article
Subjects: WC Communicabable diseases
Divisions: Clinical Support > Immunology
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Depositing User: Miss Emily Johnson
Date Deposited: 04 Jun 2021 12:03
Last Modified: 04 Jun 2021 12:03
URI: http://www.repository.uhblibrary.co.uk/id/eprint/4387

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