S-Variant SARS-CoV-2 Lineage B1.1.7 Is Associated With Significantly Higher Viral Load in Samples Tested by TaqPath Polymerase Chain Reaction.

Kidd, Michael, Richter, Alex, Best, Angus, Cumley, Nicola, Mirza, Jeremy, Percival, Benita, Mayhew, Megan, Megram, Oliver, Ashford, Fiona, White, Thomas, Moles-Garcia, Emma, Crawford, Liam, Bosworth, Andrew, Atabani, Sowsan F, Plant, Tim and McNally, Alan (2021) S-Variant SARS-CoV-2 Lineage B1.1.7 Is Associated With Significantly Higher Viral Load in Samples Tested by TaqPath Polymerase Chain Reaction. The Journal of infectious diseases, 223 (10). pp. 1666-1670. ISSN 1537-6613.

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Official URL: https://jid.oxfordjournals.org/

Abstract

A SARS-CoV-2 variant B1.1.7 containing mutation Δ69/70 has spread rapidly in the United Kingdom and shows an identifiable profile in ThermoFisher TaqPath RT-qPCR, S gene target failure (SGTF). We analyzed recent test data for trends and significance. Linked cycle threshold (Ct) values for respiratory samples showed that a low Ct for ORF1ab and N were clearly associated with SGTF. Significantly more SGTF samples had higher inferred viral loads between 1×107 and 1×108. Our conclusion is that patients whose samples exhibit the SGTF profile are more likely to have high viral loads, which may explain higher infectivity and rapidity of spread.

Item Type: Article
Subjects: QW Microbiology. Immunology
QZ Pathology. Oncology
W Public health. Health statistics. Occupational health. Health education
Divisions: Clinical Support > Infectious Diseases
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Depositing User: Jamie Edgar
Date Deposited: 14 Jun 2021 09:29
Last Modified: 14 Jun 2021 09:29
URI: http://www.repository.uhblibrary.co.uk/id/eprint/4432

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