The clinical course of COVID-19 in pregnant versus non-pregnant women requiring hospitalisation: results from the multicentre UK CA-COVID-19 study.

Crossette-Thambiah, Christina, Nicholson, Pip, Rajakaruna, Indika, Langridge, Alexander, Sayar, Zara, Perelta, Maria Rita, Essex, Sarah, Oakes, Roderick, Mounter, Philip, Lewis, Sarah, Dutt, Tina, Scott, Ian, Aung, NiNi, Shapiro, Susie, Laffan, Mike and Arachchillage, Deepa Rj (2021) The clinical course of COVID-19 in pregnant versus non-pregnant women requiring hospitalisation: results from the multicentre UK CA-COVID-19 study. British journal of haematology. ISSN 1365-2141. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: http://onlinelibrary.wiley.com/journal/10.1111/(IS...

Abstract

The impact of COVID-19 infection on pregnant women remains relatively unknown but the physiological changes of pregnancy and hypercoagulability of COVID-19 may further increase thrombotic risk. In this retrospective multicentre observational study, we report clinical characteristics and outcomes in 36 pregnant women requiring hospitalisation for COVID-19 compared to a propensity matched cohort of non-pregnant women. Pregnant women had lower haemoglobin and higher lymphocyte counts but no differences in other haematological or biochemical parameters on admission compared to non-pregnant women. There was no significant difference in the duration of hospitalisation; median 2days (1-77) for pregnant women vs 8days (1-49) for non-pregnant. A higher proportion of non-pregnant women required mechanical ventilation [11/36 (31%) vs 3/36 (8%), p=0.03] and received thromboprophylaxis with low molecular weight heparin within 24hrs of admission [25/36 (69%) vs 15 /36(42%), p=0.03] compared to pregnant women. One pregnant woman required extracorporeal membrane oxygenation. Rate of thrombosis was similar in both groups (1 in each group). No women developed major bleeding or died. Data suggests that although non-pregnant women had severe clinical course, overall outcomes were not different between women with or without pregnancy. Use of thromboprophylaxis was inconsistent, demonstrating a need for establishing evidence-based guidance for COVID-19 during pregnancy.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: QA Mathematics. Computing
WH Haemic and lymphatic systems. Haematology
Divisions: Planned IP Care > Oncology and Clinical Haematology
Related URLs:
Depositing User: Jamie Edgar
Date Deposited: 21 Jun 2021 13:52
Last Modified: 21 Jun 2021 13:52
URI: http://www.repository.uhblibrary.co.uk/id/eprint/4444

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