How Machine Perfusion Ameliorates Hepatic Ischaemia Reperfusion Injury.

Clarke, George, Mergental, Hynek, Hann, Angus, Perera, M Thamara P R, Afford, Simon C and Mirza, Darius F (2021) How Machine Perfusion Ameliorates Hepatic Ischaemia Reperfusion Injury. International journal of molecular sciences, 22 (14). ISSN 1422-0067. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Abstract

The increasing disparity between the number of patients listed for transplantation and the number of suitable organs has led to the increasing use of extended criteria donors (ECDs). ECDs are at increased risk of developing ischaemia reperfusion injury and greater risk of post-transplant complications. Ischaemia reperfusion injury is a major complication of organ transplantation defined as the inflammatory changes seen following the disruption and restoration of blood flow to an organ-it is a multifactorial process with the potential to cause both local and systemic organ failure. The utilisation of machine perfusion under normothermic (37 degrees Celsius) and hypothermic (4-10 degrees Celsius) has proven to be a significant advancement in organ preservation and restoration. One of the key benefits is its ability to optimise suboptimal organs for successful transplantation. This review is focused on examining ischaemia reperfusion injury and how machine perfusion ameliorates the graft's response to this.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: QW Microbiology. Immunology
WI Digestive system. Gastroenterology
Divisions: Planned IP Care > Gastroentrology
Related URLs:
Depositing User: Jamie Edgar
Date Deposited: 04 Aug 2021 08:55
Last Modified: 04 Aug 2021 08:55
URI: http://www.repository.uhblibrary.co.uk/id/eprint/4528

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