The contemporary role of MRI in the monitoring and management of people with multiple sclerosis in the UK.

Fernandes, Linford, Allen, Christopher Martin, Williams, Thomas, Tallantyre, Emma, Evangelou, Nikos, Chataway, Jeremy and Ford, Helen L (2021) The contemporary role of MRI in the monitoring and management of people with multiple sclerosis in the UK. Multiple sclerosis and related disorders, 55. p. 103190. ISSN 2211-0356. This article is available to all UHB staff and students login using a UHB Athens Account. Register for Athens here - https://openathens.nice.org.uk/

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Official URL: http://www.journals.elsevier.com/multiple-sclerosi...

Abstract

BACKGROUND

Compare the contemporary use of magnetic resonance imaging (MRI) in the monitoring and management of people with MS in the UK to current consensus guidelines.

METHODS

This retrospective multicentre audit of clinical practice gathered data on 2567 patients with MS from 25 MS centres across the UK.

RESULTS

Routine monitoring (44.7%), and recent clinical relapse (20.3%) were the most common scan indications. In routine monitoring, the addition of spinal imaging to brain showed no significant difference in disease modifying treatment (DMT) decision at subsequent clinical review. Approximately 1 in 5 gadolinium administered scans showed enhancement, and in 1 in 20 patients, gadolinium enhancement was the only evidence of radiological disease activity. Mean inter-scan intervals in relapsing-remitting MS for routine monitoring was 19.2 months (SD 20.7) with wide variation between centres. Only 53.8% of patients under progressive multifocal leukoencephalopathy (PML) surveillance met the recommended scanning frequency. MRI protocols demonstrated heterogeneity in the sequences used for diagnostic, monitoring and PML surveillance scans.

CONCLUSIONS

MS centres across the UK demonstrate varied practice and protocols when using MRI to monitor people with MS. In this cohort, gadolinium use and spinal imaging demonstrates limited impact on subsequent DMT decisions.

Item Type: Article
Additional Information: This article is available to all UHB staff and students login using a UHB Athens Account. Register for Athens here - https://openathens.nice.org.uk/
Subjects: WL Nervous system. Neurology
WN Medical imaging. Radiology
Divisions: Emergency Services > Neurology
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Depositing User: Jamie Edgar
Date Deposited: 17 Aug 2021 14:48
Last Modified: 05 May 2022 07:26
URI: http://www.repository.uhblibrary.co.uk/id/eprint/4549

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