Development and validation of an improved classification and risk stratification system for carotid body tumors: A multinational collaborative cohort study.

Mehanna, Hisham, Mistry, Pankaj, Golusinski, Pawel, Di Maio, Pasquale, Nankivell, Paul C, Snider, Francesco, Ferrante, Angela M R, Montalto, Nausica, Nicolai, Piero, Marcantoni, Alessandra, Grandi, Cesare, Zavatta, Marco, Grego, Franco, Malec, Kataryna, Hosal, Sefik, Suslu, Nilda, Kuscu, Oguz, Torrealba, Ignacio, Valdes, Francisco, Sharma, Neil, Ayuk, John, Monksfield, Peter, Irving, Richard, Dunn, Janet A, Kay, Mark and Borsetto, Daniele (2021) Development and validation of an improved classification and risk stratification system for carotid body tumors: A multinational collaborative cohort study. Head & neck. ISSN 1097-0347. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: http://onlinelibrary.wiley.com/journal/10.1002/(IS...

Abstract

BACKGROUND

This study aims to develop and validate a new classification system that better predicts combined risk of neurological and neurovascular complications following CBT surgery, crucial for treatment decision-making.

METHODS

Multinational retrospective cohort study with 199 consecutive cases. A cohort of 132 CBT cases was used to develop the new classification. To undertake external validation, assessment was made between the actual complication rate and predicted risk by the model on an independent cohort (n = 67).

RESULTS

Univariate analyses showed statistically significant associations between developing a complication and the following factors: craniocaudal dimension, volume, Shamblin classification, and Mehanna types. In the multivariate prognostic model, only Mehanna type remained as a significant risk predictor. The risk of developing complications increases with increasing Mehanna type.

CONCLUSIONS

We have developed and then validated a new classification and risk stratification system for CBTs, which demonstrated better prognostic power for the risk of developing neurovascular complications after surgery.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WO Surgery
WV Otorhinolaryngology. ENT medicine
Divisions: Ambulatory Care > ENT
Related URLs:
Depositing User: Jamie Edgar
Date Deposited: 02 Sep 2021 12:04
Last Modified: 02 Sep 2021 12:04
URI: http://www.repository.uhblibrary.co.uk/id/eprint/4601

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