Well-differentiated gastroenteropancreatic G3 NET: findings from a large single centre cohort.

Lithgow, K, Venkataraman, Hema, Hughes, S J, Shah, H, Kemp-Blake, J, Vickrage, S, Smith, Samuel C L, Humphries, S, Elshafie, Mona, Taniere, Phillipe, Diaz-Cano, S, Dasari, B V M, Almond, Max, Ford, Samuel J, Ayuk, John, Shetty, Shishir, Shah, Tahir and Geh, Ian (2021) Well-differentiated gastroenteropancreatic G3 NET: findings from a large single centre cohort. Scientific reports, 11 (1). p. 17947. ISSN 2045-2322. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Abstract

Neuroendocrine neoplasms are known to have heterogeneous biological behavior. G3 neuroendocrine tumours (NET G3) are characterized by well-differentiated morphology and Ki67 > 20%. The prognosis of this disease is understood to be intermediate between NET G2 and neuroendocrine carcinoma (NEC). Clinical management of NET G3 is challenging due to limited data to inform treatment strategies. We describe clinical characteristics, treatment, and outcomes in a large single centre cohort of patients with gastroenteropancreatic NET G3. Data was reviewed from 26 cases managed at Queen Elizabeth Hospital, Birmingham, UK, from 2012 to 2019. Most commonly the site of the primary tumour was unknown and majority of cases with identifiable primaries originated in the GI tract. Majority of cases demonstrated somatostatin receptor avidity. Median Ki67 was 30%, and most cases had stage IV disease at diagnosis. Treatment options included surgery, somatostatin analogs (SSA), and chemotherapy with either platinum-based or temozolomide-based regimens. Estimated progression free survival was 4 months following initiation of SSA and 3 months following initiation of chemotherapy. Disease control was observed following treatment in 5/11 patients treated with chemotherapy. Estimated median survival was 19 months; estimated 1 year survival was 60% and estimated 2 year survival was 13%. NET G3 is a heterogeneous group of tumours and patients which commonly have advanced disease at presentation. Prognosis is typically poor, though select cases may respond to treatment with SSA and/or chemotherapy. Further study is needed to compare efficacy of different treatment strategies for this disease.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: QZ Pathology. Oncology
WG Cardiovascular system. Cardiology
WK Endocrine system. Endocrinology
WN Medical imaging. Radiology
WO Surgery
Divisions: Planned IP Care > Gastroentrology
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Depositing User: Jamie Edgar
Date Deposited: 21 Sep 2021 12:09
Last Modified: 21 Sep 2021 12:09
URI: http://www.repository.uhblibrary.co.uk/id/eprint/4663

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