Tan, Bee K, Chen, Jing, Hu, Jiamiao, Amar, Omar, Mattu, Harman S, Ramanjaneya, Manjunath, Patel, Vanlata, Lehnert, Hendrik and Randeva, Harpal S (2014) Circulatory changes of the novel adipokine adipolin/CTRP12 in response to metformin treatment and an oral glucose challenge in humans. Clinical endocrinology. ISSN 1365-2265.
Full text not available from this repository.Abstract
OBJECTIVE
Adipolin/CTRP12 is a novel adipokine with anti-inflammatory and glucose-lowering properties in rodents. We sought to investigate the effects of metformin treatment (850 mg twice daily for 6 months) and a 2 h 75 g oral glucose tolerance test (OGTT) on serum adipolin concentrations in humans.
DESIGN
Cross-sectional study [PCOS (n = 83) and control (n = 39) subjects]. Serum adipolin was measured by ELISA. Metformin treatment (850 mg twice daily for 6 months) was offered to all women with PCOS, 34 women participated but 21 women completed 6 months of metformin therapy. Reasons for subjects not completing the study were nausea and gastrointestinal side effects (n = 4), pregnancies (n = 5), noncompliance (n = 2) and loss of contact (n = 2).
RESULTS
Metformin treatment (850 mg twice daily for 6 months) substantially increased serum adipolin concentrations (P < 0·05) in women with polycystic ovary syndrome (PCOS), a pro-inflammatory state associated with obesity, diabetes, dyslipidaemia and atherosclerosis. Furthermore, changes in waist-hip ratio, glucose, triglycerides, CRP and carotid intima media thickness showed significant negative associations with changes in adipolin levels (P < 0·05, P < 0·01); in multiple regression analyses, only changes in glucose were predictive of changes in adipolin levels (β = -0·570, P = 0·009). Serum adipolin decreased significantly in response to the OGTT in PCOS and control subjects at 90 min (P < 0·05) and 120 min (P < 0·01).
CONCLUSIONS
Adipolin and/or novel pharmacologic agents that increase adipolin's circulating concentrations might constitute a novel approach in the treatment of insulin resistant states.
Item Type: | Article |
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Subjects: | WK Endocrine system. Endocrinology |
Divisions: | Womens and Childrens > Gynaecology Womens and Childrens > Obstetrics |
Related URLs: | |
Depositing User: | Mrs Yolande Brookes |
Date Deposited: | 19 Aug 2014 10:21 |
Last Modified: | 19 Aug 2014 10:21 |
URI: | http://www.repository.uhblibrary.co.uk/id/eprint/540 |
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