Hypercoagulation in colorectal cancer: what can platelet indices tell us?

Seretis, Charalampos, Youssef, Haney and Chapman, Mark (2015) Hypercoagulation in colorectal cancer: what can platelet indices tell us? Platelets, 26 (2). pp. 114-8. ISSN 1369-1635. This article is accessible to all HEFT staff and students via NICE journals and databases http://www.nice.org.uk/about/what-we-do/evidence-services/journals-and-databases by using their HEFT Athens login IDs

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Abstract

Colorectal cancer, as all solid malignancies, is accompanied by changes in the haemostatic mechanism favoring the establishment of a thrombotic potential, with platelets playing a key-role in this framework; they further link colorectal cancer progression and hypercoagulation with the immune-response against the neoplastic spread. Under this rationale, various studies have assessed the use of platelet indices as prognostic markers of the biological behavior of colorectal cancer, demonstrating significant results. We herein attempt to summarize in a narrative and critical approach the relevant available data and the underlying pathophysiology, stressing the necessity of a more thorough understanding and future implementation of platelet indices in all stages of care we deliver to colorectal cancer patients.

Item Type:	Article
Additional Information:	This article is accessible to all HEFT staff and students via NICE journals and databases http://www.nice.org.uk/about/what-we-do/evidence-services/journals-and-databases by using their HEFT Athens login IDs
Subjects:	WI Digestive system. Gastroenterology
Divisions:	Planned IP Care > Gastroentrology Planned IP Care > General Surgery
Related URLs:	http://www.ncbi.nlm.nih.gov/pubmed/?term...
Depositing User:	Mrs Caroline Tranter
Date Deposited:	31 May 2015 07:20
Last Modified:	31 May 2015 07:20
URI:	http://www.repository.uhblibrary.co.uk/id/eprint/940

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