Is there a difference in progression of renal disease between South Asian and white European diabetic adults with moderately reduced kidney function?

Pallayova, Maria, Rayner, Hugh C, Taheri, Shahrad and Dasgupta, Indranil (2015) Is there a difference in progression of renal disease between South Asian and white European diabetic adults with moderately reduced kidney function? Journal of diabetes and its complications. ISSN 1873-460X. This article is accessible to all HEFT staff and students via NICE journals and databases http://www.nice.org.uk/about/what-we-do/evidence-services/journals-and-databases by using their HEFT Athens login IDs

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Official URL: http://www.jdcjournal.com/article/S1056-8727(15)00...

Abstract

AIMS

We examined potential ethnicity-related differences in progression of chronic kidney disease (CKD) between South Asian and white European diabetic adults with CKD stage 3 over a 5-year period.

METHODS

We analysed data collected from diabetic adults of white European and South Asian ethnicity who had attended diabetes and diabetes-renal outpatient clinics with baseline estimated glomerular filtration rate (eGFR) values ≥30 and <60ml/min/1.73m(2) over 5years (2005-2010); 891 (76%) were white Europeans, 282 (24%) were South Asians.

RESULTS

Despite similar baseline eGFR (P=0.103), South Asians were younger [median (interquartile range) 68 (63-73) vs. 70 (64-77) years; P<0.001] and had worse baseline glycated haemoglobin than white Europeans [8.0 (7.0-9.1) vs. 7.6 (6.8-8.7)%; P=0.004]. The 5-year follow-up eGFR and the decline in eGFR did not differ between the two groups. Thirty-five (12.4%) South Asians and 82 (9.2%) white Europeans progressed to stages 4-5 CKD (P=0.112). There was a trend towards higher follow-up glycated haemoglobin levels in South Asians (P=0.064).

CONCLUSIONS

Despite worse glycaemic control, South Asian diabetic adults with CKD stage 3 did not show any difference in 5-year decline in eGFR compared with white Europeans. These data do not support ethnic differences in progression of CKD between the South Asian and white European patient populations.

Item Type: Article
Additional Information: This article is accessible to all HEFT staff and students via NICE journals and databases http://www.nice.org.uk/about/what-we-do/evidence-services/journals-and-databases by using their HEFT Athens login IDs
Subjects: WJ Urogenital system. Urology
WK Endocrine system. Endocrinology
Divisions: Emergency Services > Renal
Related URLs:
Depositing User: Preeti Puligari
Date Deposited: 29 Jun 2015 13:51
Last Modified: 29 Jun 2015 14:39
URI: http://www.repository.uhblibrary.co.uk/id/eprint/993

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